KalmPro, a natural anxiety and depression supplement, has been reformulated to relieve both anxiety and depression. It was important to include even more ingredients than the original KalmPro formulation, as many people with anxiety also have depression. On the other hand, many people with depression also have anxiety. So the reformulated KalmPro was designed to address both anxiety and depressive symptoms, as both go hand-in-hand. Insomnia, or difficulty sleeping, is also a common problem that goes along with anxiety and depression. So it was important for KalmPro to address insomnia as well.
This is why KalmPro was reformulated, to address the symptoms of anxiety, depression, and insomnia. The original KalmPro formulation only had 5 ingredients to help for anxiety. The new, reformulated KalmPro now has 14 ingredients to help for anxiety, depression, and insomnia. As an added bonus, there are ingredients in KalmPro which also help for improving concentration, as concentration problems also go along with anxiety and depression.
If you look at what is available on the market now, there is only one natural anxiety and depression supplement- KalmPro.
The reformulated KalmPro contains the following ingredients:
- B Complex Vitamins–
Research shows that B complex vitamins, which include B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), and B7 (biotin), are effective for reducing anxiety and depressive symptoms (1).
Magnesium is known be a treatment for anxiety and can help depression as an augmenting agent. When vitamin B6 is combined with magnesium, it is especially effective for anxiety (2).
- Rhodiola Extract–
Multiple studies show that Rhodiola can reduce anxiety symptoms in Generalized Anxiety Disorder (GAD), but recently has also been found to be effective for mild to moderate depression (3, 4).
Several studies show that Ashwagandha can relieve anxiety symptoms by stabilizing the body’s response to stress (5).
–Research shows that Chamomile can reduce anxiety in Generalized Anxiety Disorder (GAD) by enhancing GABA and serotonin (6).
GABA is an inhibitory neurotransmitter in the brain which reduces hyperactive fear circuits, and is effective for phobic anxiety (7).
- Lemon Balm–
Lemon Balm enhances GABA and reduces stress-induced corticosteroids to help with anxiety and insomnia (8, 9).
Skullcap enhances GABA and is a GABA receptor agonist, which helps to decrease anxiety symptoms (10).
Bacopa helps to reduce anxiety symptoms and has been known to improve memory and concentration (11).
- Passion Flower–
Passionflower is a GABA reuptake inhibitor and enhances GABA, which research shows to be effective for Generalized Anxiety Disorder (GAD) and anxiety before surgery (12, 13).
Valerian enhances GABA activity and is used to treat Obsessive Compulsive Disorder (OCD) (8).
L-Theanine is an amino acid found in green tea, and is effective at reducing anxiety. It enhances GABA and serotonin in the brain (8).
- St. John’s Wort–
St. John’s Wort is an herbal supplement that is effective for depression, and its effect is similar to antidepressant medications. It modulates the neurotransmitters serotonin, dopamine, noradrenaline, GABA, and glutamate in brain areas that are affected in depression (14).
5-HTP is the precursor to 5-HT, also known as serotonin, which is effective for depression (15).
As you can see, the new and reformulated KalmPro has many natural ingredients that studies show to be effective for anxiety and depression, with an added benefit of helping to improve sleep and concentration. KalmPro is the best natural anxiety and depression supplement, formulated by a psychiatrist.
- Lewis JE, Tiozzo E, Melillo AB, Leonard S, Chen L, Mendez A, Woolger JM, Konefal J. The effect of methylated vitamin B complex on depressive and anxiety symptoms and quality of life in adults with depression. ISRN Psychiatry. 2013 Jan 21;2013:621453. doi: 10.1155/2013/621453. Print 2013. PubMed PMID: 23738221; PubMed Central PMCID: PMC3658370.
- Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review.Nutrients. 2017 Apr 26;9(5). pii: E429. doi: 10.3390/nu9050429. Review. PubMed PMID: 28445426; PubMed Central PMCID: PMC5452159.
- Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med. 2008 Mar;14(2):175-80. doi: 10.1089/acm.2007.7117. PubMed PMID: 18307390.
- Pratte MA, Nanavati KB, Young V, Morley CP. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). J Altern Complement Med. 2014 Dec;20(12):901-8. doi: 10.1089/acm.2014.0177. Review. PubMed PMID: 25405876; PubMed Central PMCID: PMC4270108.
- Bangratz M, Ait Abdellah S, Berlin A, Blondeau C, Guilbot A, Dubourdeaux M, Lemoine P. A preliminary assessment of a combination of rhodiola and saffron in the management of mild-moderate depression. Neuropsychiatr Dis Treat. 2018 Jul 13;14:1821-1829. doi: 10.2147/NDT.S169575. eCollection 2018. PubMed PMID: 30034237; PubMed Central PMCID: PMC6049049.
- Amsterdam JD, Li Y, Soeller I, Rockwell K, Mao JJ, Shults J. A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. J Clin Psychopharmacol. 2009 Aug;29(4):378-82. doi: 10.1097/JCP.0b013e3181ac935c. PubMed PMID: 19593179; PubMed Central PMCID: PMC3600416.
- Abdou AM, Higashiguchi S, Horie K, Kim M, Hatta H, Yokogoshi H. Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. Biofactors. 2006;26(3):201-8. PubMed PMID: 16971751.
- “Chapter 14- Natural Supplements for Anxiety Disorders.” Anxiety Protocol. Carandang C. 2014. Healthy Mind Research Corporation.
- Yoo DY, Choi JH, Kim W, Yoo KY, Lee CH, Yoon YS, Won MH, Hwang IK. Effects of Melissa officinalis L. (lemon balm) extract on neurogenesis associated with serum corticosterone and GABA in the mouse dentate gyrus. Neurochem Res. 2011 Feb;36(2):250-7. doi: 10.1007/s11064-010-0312-2. Epub 2010 Nov 13. PubMed PMID: 21076869.
- Alramadhan E, Hanna MS, Hanna MS, Goldstein TA, Avila SM, Weeks BS. Dietary and botanical anxiolytics. Med Sci Monit. 2012 Apr;18(4):RA40-8. Review. PubMed PMID: 22460105; PubMed Central PMCID: PMC3560823.
- Sathyanarayanan V, Thomas T, Einöther SJ, Dobriyal R, Joshi MK, Krishnamachari S. Brahmi for the better? New findings challenging cognition and anti-anxiety effects of Brahmi (Bacopa monniera) in healthy adults. Psychopharmacology (Berl). 2013 May;227(2):299-306. doi: 10.1007/s00213-013-2978-z. Epub 2013 Jan 26. PubMed PMID: 23354535.
- “Passionflower.” Retrieved from https://nccih.nih.gov/health/passionflower. National Center for Complementary and Integrative Health (NCCIH). 2014.
- Modulation of the γ-aminobutyric acid (GABA) system by Passiflora incarnata L. Appel K, Rose T, Fiebich B, Kammler T, Hoffmann C, Weiss G. Phytother Res. 2011 Jun;25(6):838-43.
- Maher AR, Hempel S, Apaydin E, Shanman RM, Booth M, Miles JN, Sorbero ME. St. John’s Wort for Major Depressive Disorder: A Systematic Review. Rand Health Q. 2016 May 9;5(4):12. eCollection 2016 May 9. PubMed PMID: 28083422; PubMed Central PMCID: PMC5158227.
- van Praag HM. In search of the mode of action of antidepressants: 5-HTP/tyrosine mixtures in depression. Adv Biochem Psychopharmacol. 1984;39:301-14. PubMed PMID: 6380226.
Carlo Carandang, MD, is a psychiatrist and licensed physician, who has over 15 years experience treating patients with depression and anxiety. In addition, Dr. Carlo has done research and taught students and doctors about depression and anxiety. His other popular website, AnxietyBoss.com, has received over 4 million views to date.